Researchers on the undersea lab Aquatica have genetically altered the brains of captive sharks to develop a cure for Alzheimer's disease. But there's an unexpected side effect: the sharks got smarter, faster, and more dangerous. After a big storm damages their remote research facility, they must fight for their lives.
| Actor | Role |
|---|---|
 Saffron BurrowsDr. Susan McAlester | Dr. Susan McAlester |
 Thomas JaneCarter Blake | Carter Blake |
 LL Cool JPreacher | Preacher |
 Samuel L. JacksonRussell Franklin | Russell Franklin |
 Jacqueline McKenzieJanice Higgins | Janice Higgins |
 Michael RapaportTom Scoggins | Tom Scoggins |
 Stellan SkarsgårdJim Whitlock | Jim Whitlock |
 Aida TurturroBrenda Kerns | Brenda Kerns |
 CristosBoat Captain | Boat Captain |
| DDaniel ReyHelicopter Pilot | Helicopter Pilot |
 Valente RodriguezHelicopter Co-Pilot | Helicopter Co-Pilot |
 Brent RoamHelicopter Winch Operator | Helicopter Winch Operator |
 Eyal PodellBoy #1 | Boy #1 |
 Erinn BartlettGirl #1 | Girl #1 |
 Dan ThielBoy #2 | Boy #2 |
 Sabrina GeerinckxGirl #2 | Girl #2 |
| TTajsha ThomasFriend of Janice | Friend of Janice |
 Frank WelkerParrot Sounds (voice) | Parrot Sounds (voice) |
 Mary Kay BergmanParrot (voice) (uncredited) | Parrot (voice) (uncredited) |
 Ronny CoxFranklin's boss (uncredited) | Franklin's boss (uncredited) |