A husband and wife suffering from an undefinable defect in their relationship seek guidance from an "alternative" therapist who advises them to take a weekend vacation to Joshua Tree and drop acid together as a antidote to their problematic marriage. But not all trips go as planned.
| Actor | Role |
|---|---|
 Paul ScheerMichael Hodorowitz | Michael Hodorowitz |
 Maria BamfordAriel | Ariel |
 Angela GulnerDebbie | Debbie |
 Zack GoldDoug | Doug |
 Larry KingFear | Fear |
 Rene Michelle ArandaBunny | Bunny |
| LLara Thomas DuceyDepressed Debbie | Depressed Debbie |
| SSean FrenchManatee | Manatee |
| TTroy GuthrieBear | Bear |
| PPeres OwinoThe Universe | The Universe |
 Ernest PiercePoolman | Poolman |
| AAl ThompsonTruth | Truth |