 Dwayne JohnsonKrypto the Superdog / Anubis / Black Adam (voice) | Krypto the Superdog / Anubis / Black Adam (voice) |
 Kevin HartAce the Bat-Hound (voice) | Ace the Bat-Hound (voice) |
 John KrasinskiClark Kent / Superman (voice) | Clark Kent / Superman (voice) |
 Keanu ReevesBruce Wayne / Batman (voice) | Bruce Wayne / Batman (voice) |
 Kate McKinnonLulu (voice) | Lulu (voice) |
 Vanessa BayerPB (voice) | PB (voice) |
 Natasha LyonneMerton (voice) | Merton (voice) |
 Diego LunaChip (voice) | Chip (voice) |
 Jameela JamilDiana Prince / Wonder Woman (voice) | Diana Prince / Wonder Woman (voice) |
 Marc MaronLex Luthor (voice) | Lex Luthor (voice) |
 Dascha PolancoJessica Cruz / Green Lantern (voice) | Jessica Cruz / Green Lantern (voice) |
 Olivia WildeLois Lane (voice) | Lois Lane (voice) |
 Jemaine ClementArthur Curry / Aquaman (voice) | Arthur Curry / Aquaman (voice) |
 Daveed DiggsVictor Stone / Cyborg (voice) | Victor Stone / Cyborg (voice) |
 John EarlyBarry Allen / The Flash (voice) | Barry Allen / The Flash (voice) |
 Ben SchwartzMark / Fire Guinea Pig (voice) | Mark / Fire Guinea Pig (voice) |
 Thomas MiddleditchKeith / Ice Guinea Pig (voice) | Keith / Ice Guinea Pig (voice) |
 Maya ErskineMercy Graves (voice) | Mercy Graves (voice) |
 Yvette Nicole BrownPatty (voice) | Patty (voice) |
 Alfred MolinaJor-El (voice) | Jor-El (voice) |
 Lena HeadeyLara (voice) | Lara (voice) |
 Keith DavidDog-El (voice) | Dog-El (voice) |
 Busy PhilippsFoofy Dog (voice) | Foofy Dog (voice) |
 Dan FoglerCarl / Pilot / Racer (voice) | Carl / Pilot / Racer (voice) |
| WWinona BradshawWhiskers (voice) | Whiskers (voice) |
 David PressmanCorgi (voice) | Corgi (voice) |
 Sam LevineWaffles / Robot Guards (voice) | Waffles / Robot Guards (voice) |
 Jared SternBathtub Guy / JLA Hotline (voice) | Bathtub Guy / JLA Hotline (voice) |
 Michelle MorganMech Suit (voice) | Mech Suit (voice) |
| AAmanda AmesGuinea-Pigasus (voice) | Guinea-Pigasus (voice) |
