 Dermot MulroneyDante (voice) | Dante (voice) |
 James CromwellVirgil (voice) | Virgil (voice) |
 Olivia D'AboBeatrice (voice) | Beatrice (voice) |
 Martha PlimptonCelia / Lobbyist Singer / Lizzie Borden (voice) | Celia / Lobbyist Singer / Lizzie Borden (voice) |
 Tony AbatemarcoLying Defendant / Farinata (voice) | Lying Defendant / Farinata (voice) |
 Scott AdsitJudge Minos / Paolo / Hirohito / Copter Pilot (voice) | Judge Minos / Paolo / Hirohito / Copter Pilot (voice) |
 Matt BesserMetallica Defendant / L. Ron Hubbard (voice) | Metallica Defendant / L. Ron Hubbard (voice) |
 Bill ChottGiaccio 'El Gordo' / Calvacanti / Stalin (voice) | Giaccio 'El Gordo' / Calvacanti / Stalin (voice) |
 Andy DalyLucan / 'Right On' Glutton / Jim Jones / Airport Screener / Ulysses' Naysayer (voice) | Lucan / 'Right On' Glutton / Jim Jones / Airport Screener / Ulysses' Naysayer (voice) |
 Tony HaleOvid / Real Estate Broker / Pope Nicholas 3rd (voice) | Ovid / Real Estate Broker / Pope Nicholas 3rd (voice) |
 Tom HallickGeorge Sanders / Lobbyist (voice) | George Sanders / Lobbyist (voice) |
 Janet VarneyTeacher / Cleopatra / City of Dis Intercom / Ulysses' Usher (voice) | Teacher / Cleopatra / City of Dis Intercom / Ulysses' Usher (voice) |
 Paul ZaloomHomer / God / Officer Chiron / Southern Lobbyist / Airport Security / Caiaphas / Ulysses' Crew / Macmud / Insider Trader #1 / Nicole Ceausescu / Lucifer (voice) | Homer / God / Officer Chiron / Southern Lobbyist / Airport Security / Caiaphas / Ulysses' Crew / Macmud / Insider Trader #1 / Nicole Ceausescu / Lucifer (voice) |
 Mike ColemanCharon / Phlegyas / Senator / Dick Cheney (voice) | Charon / Phlegyas / Senator / Dick Cheney (voice) |
 Brandon JohnsonIrate Driver / Mounted Policeman / Pimp #1 / Pimp #3 / Airport Security (voice) | Irate Driver / Mounted Policeman / Pimp #1 / Pimp #3 / Airport Security (voice) |
 Matt WalshMussolini / Fox Reporter / Airport Security Pursuer (voice) | Mussolini / Fox Reporter / Airport Security Pursuer (voice) |
