Daniel Boone leads settlers into Kentucky, but must battle Shawnee Indians who have been persuaded by a French renegade that Boone and the settlers are there to kill them and steal their land.
| Actor | Role |
|---|---|
 Bruce BennettDaniel Boone | Daniel Boone |
 Lon Chaney Jr.Blackfish | Blackfish |
 Faron YoungFaron Callaway | Faron Callaway |
| KKem DibbsSimon Girty | Simon Girty |
 Damian O'FlynnAndy Callaway | Andy Callaway |
| JJacqueline EvansRebecca Boone | Rebecca Boone |
| NNancy RodmanSusannah Boone | Susannah Boone |
 Freddy Fernández 'El Pichi'Israel Boone | Israel Boone |
 Carol KellyJamima Boone | Jamima Boone |
 Eduardo NoriegaSquire Boone | Squire Boone |
 Fred Kohler Jr.Kenton | Kenton |
| GGordon MillsJohn Holder | John Holder |
 Claudio BrookJames Boone | James Boone |
| JJoe AinleyGeneral Hamilton | General Hamilton |
| LLee MorganSmitty | Smitty |