A trio of beautiful girls set out to revolutionize life at a grungy American university: the dynamic leader Violet Wister, principled Rose and sexy Heather. They welcome transfer student Lily into their group which seeks to help severely depressed students with a program of good hygiene and musical dance numbers.
| Actor | Role |
|---|---|
 Greta GerwigViolet Wister | Violet Wister |
 Lio TiptonLily | Lily |
 Megalyn EchikunwokeRose | Rose |
 Carrie MacLemoreHeather | Heather |
 Ryan MetcalfFrank | Frank |
 Jermaine CrawfordJimbo | Jimbo |
 Caitlin FitzGeraldPriss | Priss |
 Zach WoodsRick DeWolfe | Rick DeWolfe |
| DDomenico D'IppolitoComplainer Student | Complainer Student |
 Nick BlaemireFreak Astaire | Freak Astaire |
 Aubrey PlazaDepressed Debbie | Depressed Debbie |
 Hugo BeckerXavier | Xavier |
 Meredith HagnerAlice | Alice |
| JJoe CootsBarman | Barman |
 Adam BrodyFred Packenstacker / Charlie Walker | Fred Packenstacker / Charlie Walker |
 Billy MagnussenThor | Thor |
 Aja Naomi KingPositive Polly | Positive Polly |
 Alia ShawkatMad Madge | Mad Madge |
| CCortez Nance Jr.Groundskeeper | Groundskeeper |
| JJordanna DrazinEmily Tweeter | Emily Tweeter |
 Shinnerrie JacksonSharise | Sharise |
 Taylor NicholsProfessor Black | Professor Black |
 Carolyn FarinaCarolina Antonucci | Carolina Antonucci |