The friendship of Damon, the senator, and Pythias, the soldier, is famous in Ancient Syracuse.
| Actor | Role |
|---|---|
 William WorthingtonDamon | Damon |
 Herbert RawlinsonPythias | Pythias |
 Cleo MadisonHermione | Hermione |
 Ann LittleCalanthe | Calanthe |
 Lloyd IngrahamDionysius | Dionysius |
 Helen WrightArria (as Miss Wright) | Arria (as Miss Wright) |
| CChandler HouseSon of Damon | Son of Damon |
 Harry DavenportPhillistus (as H. Davenport) | Phillistus (as H. Davenport) |
| DDuke WorneLuculus (as H.B. Worne) | Luculus (as H.B. Worne) |
| EEdgar KellerDemocles | Democles |
| BBruce MitchellPerocles | Perocles |
 Lon ChaneyWild Man (uncredited) (unconfirmed) | Wild Man (uncredited) (unconfirmed) |
 Carmen PhillipsExtra (uncredited) | Extra (uncredited) |
| HHal RoachExtra (uncredited) | Extra (uncredited) |