At the end of the 21st century, the world is plagued by a mysterious virus and unusual weather. Genius scientist Dr. Kisaragi creates an android with the code name “Cutie Honey” (Mariya Nishiuchi). The android is unique in that it possesses human emotions. To save mankind, Cutie Honey goes up against an evil organization.
| Actor | Role |
|---|---|
 Mariya NishiuchiCutie Honey / Hitomi Kisaragi | Cutie Honey / Hitomi Kisaragi |
 Takahiro MiuraSeiji Hayami | Seiji Hayami |
 Nicole IshidaLady Jiru | Lady Jiru |
 Sousuke TakaokaKazuhito Uraki | Kazuhito Uraki |
 Tasuku NagaseRyuta Kimura | Ryuta Kimura |
 Ren ImaiYukiko Kiyose | Yukiko Kiyose |
 Koichi IwakiDoctor Kisaragi | Doctor Kisaragi |
| HHina FukatsuRukia | Rukia |
 Takashi NishinaNot listed | Not listed |
 Akiko KuranoNot listed | Not listed |
 Takashi SasanoNot listed | Not listed |
| KKakeru YoshiieNot listed | Not listed |