Custer's Last Fight chronicles George Armstrong Custer's final battle against the forces of Sitting Bull at the Battle of the Little Bighorn.
| Actor | Role |
|---|---|
 Francis FordGeneral George A. Custer | General George A. Custer |
 William Eagle ShirtSitting Bull | Sitting Bull |
 J. Barney SherryJames McLaughlin | James McLaughlin |
 Grace CunardNot listed | Not listed |
 Art AcordTrooper | Trooper |
 Ann LittleNot listed | Not listed |
 Lillian ChristyNot listed | Not listed |
 Charles K. FrenchNot listed | Not listed |