When Curious George is offered a special space mission, Ted (The Man in the Yellow Hat) can't deny his little friend this exciting journey, especially after Curious George completes the training. But when he crash-lands in Africa, a worried Ted goes searching, expecting the worst, only to have it turn out to be the best.
| Actor | Role |
|---|---|
 Angela BassettDr. Kulinda (voice) | Dr. Kulinda (voice) |
 John GoodmanHal Houston (voice) | Hal Houston (voice) |
 Frank WelkerCurious George (voice) | Curious George (voice) |
 Jeff BennettTed (voice) | Ted (voice) |
 Alexander PolinskyTech Andrew (voice) | Tech Andrew (voice) |
 Gwendoline YeoPopcorn Vendor / Automated Voice (voice) | Popcorn Vendor / Automated Voice (voice) |
 Phil LaMarrPlane Mechanic / Dam Operator (voice) | Plane Mechanic / Dam Operator (voice) |
 Dee Bradley BakerAdditional Voices (voice) | Additional Voices (voice) |
| SSteve JosefsonAdditional Voices (voice) | Additional Voices (voice) |