 Will FerrellTed (Man with the Yellow Hat) (voice) | Ted (Man with the Yellow Hat) (voice) |
 Drew BarrymoreMaggie (voice) | Maggie (voice) |
 David CrossJunior (voice) | Junior (voice) |
 Eugene LevyClovis (voice) | Clovis (voice) |
 Joan PlowrightMs. Plushbottom (voice) | Ms. Plushbottom (voice) |
 Dick Van DykeMr. Bloomsberry (voice) | Mr. Bloomsberry (voice) |
 Frank WelkerGeorge (voice) | George (voice) |
 Ed O'RossIvan (voice) | Ivan (voice) |
| MMichael ChinyamurindiEdu (voice) | Edu (voice) |
 Michael Sorich"Seen It" Cab Driver (voice) | "Seen It" Cab Driver (voice) |
 Billy WestManager (voice) | Manager (voice) |
 Jeff BennettSalesman (voice) | Salesman (voice) |
 Kath SoucieAnimal Control Receptionist (voice) | Animal Control Receptionist (voice) |
 Clint HowardBalloon Man (voice) | Balloon Man (voice) |
 Shane BaumelKid (voice) | Kid (voice) |
| TTimyra-Joi BeattyKid (voice) | Kid (voice) |
| CChristopher ChenKid (voice) | Kid (voice) |
 Michaela Jill MurphyKid (voice) | Kid (voice) |
 Alexander GouldKid (voice) | Kid (voice) |
 Terrence Hardy Jr.Kid (voice) | Kid (voice) |
 Hailey Noelle JohnsonKid (voice) | Kid (voice) |
 Kelsey LansdowneKid (voice) | Kid (voice) |
 Ariel WinterKid (voice) | Kid (voice) |
 Kimberly BrooksAdditional Voices (voice) | Additional Voices (voice) |
 Wendy CutlerAdditional Voices (voice) | Additional Voices (voice) |
 Joey D'AuriaAdditional Voices (voice) | Additional Voices (voice) |
 Richard EpcarAdditional Voices (voice) | Additional Voices (voice) |
 Treva EtienneAdditional Voices (voice) | Additional Voices (voice) |
| EEddie FriersonAdditional Voices (voice) | Additional Voices (voice) |
 Donald FulliloveAdditional Voices (voice) | Additional Voices (voice) |
