Pioneering documentary maker Philomena Cunk returns with her most ambitious quest to date: venturing right up the universe and everything to examine life and existence in an attempt to find out the point of it all. Along the way, she interrogates experts on subjects from the big bang to biology and art to artificial intelligence. Really get to the nub of it.
| Actor | Role |
|---|---|
 Diane MorganPhilomena Cunk | Philomena Cunk |
 Douglas HedleySelf | Self |
| RRupert SheldrakeSelf | Self |
| AAlison WrightSelf | Self |
| CCelia Deane-DrummondSelf | Self |
 Paul NurseSelf | Self |
 Jim Al-KhaliliSelf | Self |
| JJoyce HarperSelf | Self |
| PProkar DasguptaSelf | Self |
| AAnil SethSelf | Self |
 Ruth AdamsSelf | Self |
| JJoanna WoodallSelf | Self |
| GGregory DartSelf | Self |
| SStephen CaseSelf | Self |
| RRuth ChangSelf | Self |
| PPeter KailSelf | Self |
| RRichard ThomsonSelf | Self |
 Brian CoxSelf | Self |
 Michelle GreenidgeJacqui Flink | Jacqui Flink |
 Charles AitkenWaylon Jackalope IV | Waylon Jackalope IV |
 Genevieve GauntPuppet (voice) | Puppet (voice) |
 Kat KumarPuppet (voice) | Puppet (voice) |
| JJerry WilderAdam | Adam |
 Atlanta JohnsonEve | Eve |
| RRory BrayEdwin Hubble | Edwin Hubble |
| EEleanor SeeleyMrs Hubble | Mrs Hubble |
 Greg LockettDoll Advert Voice Over (voice) | Doll Advert Voice Over (voice) |
 Charlie BrookerBBC Announcer (voice) (uncredited) | BBC Announcer (voice) (uncredited) |