A millionaire philanthropist collects the famous Crystal Skulls trying to tap into their ancient powers. It is up to a team lead by a college professor whose father disappeared searching for the 13th skull to save the world when the first 12 skulls are united and reek havoc on the earth without the control of the 13th skull.
| Actor | Role |
|---|---|
 Richard BurgiJohn Winston | John Winston |
 Wendy GlennSienna | Sienna |
 Sam RedfordMitchell | Mitchell |
 David RintoulHadden | Hadden |
 JR EspositoColonel Bailey | Colonel Bailey |
 Matt RippyTerry | Terry |
 Hugh FraserJohn Sr. | John Sr. |
 Velislav PavlovHussein | Hussein |
 Hristo MitzkovKasim | Kasim |
| TTerry RandallArcher | Archer |
| AAngela RodelLab Tech | Lab Tech |
| DDerek MorseConsole Operator | Console Operator |
 Julian KostovHadden Security | Hadden Security |
| IIliana LazarovaLaura | Laura |
| PPeter LadjevPilot | Pilot |
| LLuke CousinsReporter | Reporter |
 Sadie KatzAl Jazeara Reporter Sheila West | Al Jazeara Reporter Sheila West |
 Roxanne PallettBBC Reporter Melanie Cox | BBC Reporter Melanie Cox |
 Joe GaminaraCNN Reporter Tom Ruggles | CNN Reporter Tom Ruggles |
| EElayah RothLisa Winston | Lisa Winston |