 Joshua ZemanHimself | Himself |
 Barbara BrancaccioHerself | Herself |
| BBill EllisHimself - Professor of Folklore, Penn State | Himself - Professor of Folklore, Penn State |
| DDorothy D'ElettoHerself - Archivist & Researcher | Herself - Archivist & Researcher |
 Geraldo RiveraHimself - Reporter (archive footage) | Himself - Reporter (archive footage) |
| KKaren SchweigerHerself - Jennifer Schweiger's Mother | Herself - Jennifer Schweiger's Mother |
| DDavid NavarroHimself - Former Newscaster | Himself - Former Newscaster |
| DDonna CutugnoHerself - Founder, Friends of Jennifer | Herself - Founder, Friends of Jennifer |
| RRalph AquinoHimself - Retired Detective, NYPD | Himself - Retired Detective, NYPD |
| BBobby JensenHimself - Retired Detective, NYPD | Himself - Retired Detective, NYPD |
| EErnie AnastosHimself - Reporter (archive footage) | Himself - Reporter (archive footage) |
| AAndre RandHimself - Suspect | Himself - Suspect |
| JJim CallaghanHimself - Former Editor, Staten Island Eagle | Himself - Former Editor, Staten Island Eagle |
| JJim DolanHimself - Reporter (archive footage) | Himself - Reporter (archive footage) |
| TTheresa DoyleHerself - Searcher for Jennifer | Herself - Searcher for Jennifer |
| EEd ArmstrongHimself - Holly Ann Hughes's Brother | Himself - Holly Ann Hughes's Brother |
| SSean HughesHimself - Holly Ann Hughes's Brother (archive footage) | Himself - Holly Ann Hughes's Brother (archive footage) |
| PPeter HughesHimself - Holly Ann Hughes's Father | Himself - Holly Ann Hughes's Father |
| HHolly CederholmHerself - Holly Ann Hughes's Mother | Herself - Holly Ann Hughes's Mother |
| KKen SchweigerHimself - Jennifer Schweiger's Father | Himself - Jennifer Schweiger's Father |
| JJohn O'BrienHimself - Reporter, Staten Island Advance | Himself - Reporter, Staten Island Advance |
| DDuane FeltonHimself - Defense Attorney for Andre Rand | Himself - Defense Attorney for Andre Rand |
| LLarry SimonHimself - Defense Attorney for Andre Rand | Himself - Defense Attorney for Andre Rand |
| WWilliam L. MurphyHimself - Staten Island District Attorney | Himself - Staten Island District Attorney |
| TTrina CutugnoHerself - Donna's Daughter | Herself - Donna's Daughter |
| DDevin CutugnoHimself - Donna's Son | Himself - Donna's Son |
| JJimmy RassiasHimself - Former Clerk, Port Richmond Deli | Himself - Former Clerk, Port Richmond Deli |
| KKristine GoslingHerself - Det. Sgt. Missing Persons Squad, Long Term Cases, NYPD | Herself - Det. Sgt. Missing Persons Squad, Long Term Cases, NYPD |
| LLuis RiveraHimself - Retired Canine Officer, NYPD | Himself - Retired Canine Officer, NYPD |
| FFrank SaezHimself - Ret. Det. Missing Persons Squad, Long Term Cases, NYPD | Himself - Ret. Det. Missing Persons Squad, Long Term Cases, NYPD |
