 Michael B. JordanAdonis Johnson | Adonis Johnson |
 Sylvester StalloneRocky Balboa | Rocky Balboa |
 Tessa ThompsonBianca | Bianca |
 Wood HarrisTony 'Little Duke' Evers | Tony 'Little Duke' Evers |
 Russell HornsbyBuddy Marcelle | Buddy Marcelle |
 Phylicia RashādMary Anne Creed | Mary Anne Creed |
 Dolph LundgrenIvan Drago | Ivan Drago |
 Florian MunteanuViktor Drago | Viktor Drago |
 Andre WardDanny 'Stuntman' Wheeler | Danny 'Stuntman' Wheeler |
 Brigitte NielsenLudmilla Drago | Ludmilla Drago |
 Milo VentimigliaRobert Balboa | Robert Balboa |
 Robbie JohnsLogan Balboa | Logan Balboa |
| PPatrice HarrisPadman | Padman |
 Jacob 'Stitch' DuranStitch | Stitch |
 Ana GerenaAdrian's Waitress | Adrian's Waitress |
| BBenjamin VaynshelboymConstruction Supervisor (Russian) | Construction Supervisor (Russian) |
| AAngelina ShipilinaDebutante (Russian) | Debutante (Russian) |
| PPavel VakunovRussian Politician | Russian Politician |
 Oleg IvanovBusinessman (Russian) | Businessman (Russian) |
 Christopher MannDr. Percy Ewell | Dr. Percy Ewell |
| RRobert DouglasKyri | Kyri |
 Zack BeyerPhotographer | Photographer |
 Chrisdine KingCasino Bartender | Casino Bartender |
 James Collins Jr.Sports Bar Patron | Sports Bar Patron |
 John JeziorStage Manager / Barclays Center | Stage Manager / Barclays Center |
 Pete PostiglioneReporter | Reporter |
| BBilly VargusReporter | Reporter |
 Johanna TolentinoPharmacist | Pharmacist |
| EEleni DelopoulosNurse | Nurse |
 Marcia MyersObstetrics Nurse | Obstetrics Nurse |
