An ex-Navy seal, his girlfriend and their friends head out on a road trip to New Orleans. The group decides to stop at a roadside convenience store owned by Chopper, who tells them the tale of Lockjaw, a fabled god-like creature who is half-man, half-alligator.
| Actor | Role |
|---|---|
 Mehcad BrooksNiles | Niles |
 Serinda SwanEmily | Emily |
 Dillon CaseyOscar | Oscar |
 Lauren SchneiderKaren | Karen |
 Aaron HillRandy | Randy |
 Amanda FullerBeth | Beth |
 Wayne PéréBud | Bud |
 David JensenJimmy | Jimmy |
 Pruitt Taylor VinceGrover | Grover |
 Daniel BernhardtLockjaw / Grimley | Lockjaw / Grimley |
 Sid HaigChopper | Chopper |
 Jennifer Lynn WarrenOphelia | Ophelia |
 Lance E. NicholsOld Man | Old Man |
 Rebekah KennedyCaroline | Caroline |
| DD'Arcy AllenVillager (uncredited) | Villager (uncredited) |