It's Rob Lowe's turn to step in to the celebrity hot seat for the latest installment of The Comedy Central Roast.
| Actor | Role |
|---|---|
 David SpadeSelf - Roastmaster | Self - Roastmaster |
 Rob LoweSelf | Self |
 Jeff RossSelf | Self |
 Jimmy CarrSelf | Self |
 Pete DavidsonSelf | Self |
 Nikki GlaserSelf | Self |
 JewelSelf | Self |
 Ralph MacchioSelf | Self |
 Rob RiggleSelf | Self |
 Peyton ManningSelf | Self |
 Ann CoulterSelf | Self |
 Amy PoehlerThe Devil | The Devil |