After her younger sister gets involved in drugs and is severely injured by contaminated heroin, a nurse sets out on a mission of vengeance and vigilante justice, killing drug dealers, pimps, and mobsters who cross her path.
| Actor | Role |
|---|---|
 Pam GrierCoffy | Coffy |
 Robert DoQuiKing George | King George |
 Sid HaigOmar | Omar |
 Booker BradshawHoward Brunswick | Howard Brunswick |
 William ElliottCarter Brown | Carter Brown |
 Allan ArbusArturo Vitroni | Arturo Vitroni |
 Linda HaynesMeg | Meg |
| BBarry CahillMcHenry | McHenry |
 Lee de BrouxNick | Nick |
 Ruben MorenoRamos | Ramos |
 Lisa FarringerJeri | Jeri |
 Carol LocatellPriscilla | Priscilla |
 John PerakAleva | Aleva |
 Mwako CumbukaGrover | Grover |
 Morris BuchananSugarman | Sugarman |
 Peaches JonesJulia | Julia |
| JJan-Minika HughesBillie | Billie |
 Leslie McRayCindy | Cindy |
 Ray YoungJake | Jake |
 Bob MinorStuds | Studs |
| JJeff BurtonDr. Brannan | Dr. Brannan |
| WWally StraussDoctor | Doctor |
| DDick O'SheaDoctor #2 | Doctor #2 |
| KKim WilliamsNurse #1 | Nurse #1 |
 Ellen BlakeNurse #2 | Nurse #2 |
| LLee TerryNurse #3 | Nurse #3 |
| GGail DavisBricke Redd | Bricke Redd |
 Lyman WardOrderly | Orderly |
| DDon NewsomeAttendant | Attendant |
| KKaren WilliamsLuBelle Coffin | LuBelle Coffin |