Fearing that he costs too much to feed, Clifford decides to join a traveling carnival so he can enter a talent contest in hopes of winning a lifetime supply of Tummy Yummies treats. Joined by his friends Cleo and T-Bone, Clifford meets up with Shackleford the High-Flying Ferret and Rodrigo Chihuahua of Steel, as they work together to turn a broken-down act into a record-breaking show.
| Actor | Role |
|---|---|
 John RitterClifford the Big Red Dog (voice) | Clifford the Big Red Dog (voice) |
 Wayne BradyShackelford (voice) | Shackelford (voice) |
 Grey DeLisleEmily Elizabeth (voice) | Emily Elizabeth (voice) |
 Jenna ElfmanDorothy (voice) | Dorothy (voice) |
 John GoodmanGeorge Wolfsbottom (voice) | George Wolfsbottom (voice) |
 Jess HarnellDirk (voice) | Dirk (voice) |
 Kel MitchellT-Bone (voice) | T-Bone (voice) |
 Judge ReinholdLarry (voice) | Larry (voice) |
 Kath SoucieJetta / Madison (voice) | Jetta / Madison (voice) |
 Cree SummerCleo (voice) | Cleo (voice) |
 Wilmer ValderramaRodrigo (voice) | Rodrigo (voice) |
 Earl BoenMr. Bleakman (voice) | Mr. Bleakman (voice) |
 Cam ClarkeMr. Mark Howard / Marcus (voice) | Mr. Mark Howard / Marcus (voice) |
 Teresa GanzelLiza (voice) | Liza (voice) |
 Ernie HudsonP.T. (voice) | P.T. (voice) |
 Nick JamesonSheriff Lewis (voice) | Sheriff Lewis (voice) |
 Oren WilliamsCharley (voice) | Charley (voice) |