When fellow operatives and friends disappear during a mission in Hong Kong, Cleopatra Jones comes to help. She discovers the disappearance involves The Dragon Lady, a feared lipstick lesbian who runs a casino and the local drug trade.
| Actor | Role |
|---|---|
 Tamara DobsonCleopatra Jones | Cleopatra Jones |
 Stella StevensDragon Lady | Dragon Lady |
 Norman FellStanly Nagel | Stanly Nagel |
 Tanny Tien NiMi Ling Fong | Mi Ling Fong |
 Albert PopwellMatthew Johnson | Matthew Johnson |
 Caro KenyattaMelvin Johnson | Melvin Johnson |
 Chan ShenSoo Da Chen | Soo Da Chen |
| CChristopher HuntMendez | Mendez |
 Lin Chen-ChiMadalena | Madalena |
 John Cheung Ng-LongDavid Chang | David Chang |
 Chiang YangThug at Walled City | Thug at Walled City |
 Gam BiuMr. Han | Mr. Han |
 Lau Luk-WahTony | Tony |
 Wai PakMi Ling's Partner | Mi Ling's Partner |
 Pang PangSilk Merchant | Silk Merchant |
 Bobby CanavarroLin Ma Chen | Lin Ma Chen |
 Tony Lee Wan-MiuLao Di | Lao Di |
 Yuen Woo-pingNot listed | Not listed |
 Yen Shi-KwanNot listed | Not listed |