 David MatteyToxic Avenger / Noxious Offender | Toxic Avenger / Noxious Offender |
 Debbie RochonMs. Weiner | Ms. Weiner |
| CClyde LewisToxie (voice) | Toxie (voice) |
| HHeidi SjursenSarah / Claire | Sarah / Claire |
 Ron JeremyMayor Goldberg | Mayor Goldberg |
 Tom FulpPainter | Painter |
| PPaul KyrmseSgt. Kabukiman / Evil Kabukiman | Sgt. Kabukiman / Evil Kabukiman |
 Stan LeePrologue / Epilogue Narrator (voice) | Prologue / Epilogue Narrator (voice) |
 Joe FleishakerChester / Lardass | Chester / Lardass |
 Dan SnowSgt. Kazinski | Sgt. Kazinski |
| MMichael BudingerTito | Tito |
| LLisa TerezakisSweetie Honey | Sweetie Honey |
| BBarry BriscoPompey | Pompey |
 Corey FeldmanSarah's Gynecologist | Sarah's Gynecologist |
 Trent HaagaTex Diaper | Tex Diaper |
 Mark TorglEvil Melvin | Evil Melvin |
 Rick CollinsAmortville Police Chief | Amortville Police Chief |
 Mitch CohenLucifer | Lucifer |
 Lisa GayeAbortion Counselor | Abortion Counselor |
 James GunnDr. Flem Hocking | Dr. Flem Hocking |
 Al GoldsteinPress Secretary | Press Secretary |
 Taylor MeadAward Presenter | Award Presenter |
| YYaniv SharonRex Diaper | Rex Diaper |
 Will KeenanMan Hit by Car | Man Hit by Car |
| MMelissa BacelarDr. Hocking's Nurse | Dr. Hocking's Nurse |
 Jasi Cotton LanierWet Lesbian | Wet Lesbian |
 Lemmy KilmisterGood Lemmy / Bad Lemmy | Good Lemmy / Bad Lemmy |
 Julie StrainHerself (Facelift Death) | Herself (Facelift Death) |
 Kevin EastmanHimself (Breast Smoosh Death) | Himself (Breast Smoosh Death) |
 Tiffany ShepisBeautiful Interpretative Dancer | Beautiful Interpretative Dancer |
