Chris & Don chronicles the lifelong relationship between author Christopher Isherwood and his much younger lover, artist Don Bachardy, and it combines present-day interviews, archival footage shot by the couple from the 1950s, excerpts from Isherwood's diaries, and playful animations to recount their romance.
| Actor | Role |
|---|---|
 W.H. AudenSelf (archive footage) | Self (archive footage) |
 Ted BachardySelf | Self |
 Liza MinnelliSelf | Self |
 Gloria StuartSelf | Self |
 Michael YorkSelf - Narrator | Self - Narrator |
 Christopher MurraySelf | Self |
 Don BachardySelf | Self |