 Zach BraffChicken Little (voice) | Chicken Little (voice) |
 Garry MarshallBuck Cluck (voice) | Buck Cluck (voice) |
 Don KnottsMayor Turkey Lurkey (voice) | Mayor Turkey Lurkey (voice) |
 Amy SedarisFoxy Loxy (voice) | Foxy Loxy (voice) |
 Steve ZahnRunt of the Litter (voice) | Runt of the Litter (voice) |
 Joan CusackAbby Mallard (voice) | Abby Mallard (voice) |
 Patrick StewartMr. Woolensworth (voice) | Mr. Woolensworth (voice) |
 Fred WillardMelvin - Alien Dad (voice) | Melvin - Alien Dad (voice) |
 Catherine O'HaraTina - Alien Mom (voice) | Tina - Alien Mom (voice) |
 Wallace ShawnPrincipal Fetchit (voice) | Principal Fetchit (voice) |
 Harry ShearerDog Announcer (voice) | Dog Announcer (voice) |
 Mark WaltonGoosey Loosey (voice) | Goosey Loosey (voice) |
| SSean ElmoreKirby - Alien Kid (voice) | Kirby - Alien Kid (voice) |
 Matthew JostenKirby - Alien Kid (voice) | Kirby - Alien Kid (voice) |
| EEvan DunnKirby - Alien Kid (voice) | Kirby - Alien Kid (voice) |
 Mark DindalMorkubine Porcupine / Coach (voice) | Morkubine Porcupine / Coach (voice) |
| DDan MolinaFish Out of Water (voice) | Fish Out of Water (voice) |
 Patrick WarburtonAlien Cop (voice) | Alien Cop (voice) |
 Adam WestAce - Hollywood Chicken Little (voice) | Ace - Hollywood Chicken Little (voice) |
 Joe WhyteRodriguez / Acorn Mascot / Umpire (voice) | Rodriguez / Acorn Mascot / Umpire (voice) |
 Kelly HooverMama Runt (voice) | Mama Runt (voice) |
| WWill FinnHollywood Fish (voice) | Hollywood Fish (voice) |
 Dara McGarryHollywood Abby (voice) | Hollywood Abby (voice) |
| MMark KennedyHollywood Runt (voice) | Hollywood Runt (voice) |
 Terri DouglasAdditional Voices (voice) | Additional Voices (voice) |
 Pat FraleyAdditional Voices (voice) | Additional Voices (voice) |
 Scott MenvilleAdditional Voices (voice) | Additional Voices (voice) |
| AAaron SpannAdditional Voices (voice) | Additional Voices (voice) |
 Nathan KressAdditional Voices (voice) | Additional Voices (voice) |
 Brittney Lee HarveyAdditional Voices (voice) | Additional Voices (voice) |
