Ray and Sal, two orphaned sisters, adopt and hide a Great Dane puppy from their two adopted parents living in a luxury downtown New York apartment that expressely forbids dogs.
| Actor | Role |
|---|---|
 Abigail BreslinRay | Ray |
 Makenzie VegaSal | Sal |
| IIrene Olga LópezRosamaria | Rosamaria |
 Louis FerreiraMatt Tomley | Matt Tomley |
 Christine TucciLaura Tomley | Laura Tomley |
 Maurice GodinWesley | Wesley |
 Ethan PhillipsMarty | Marty |
 Fred EwanuickKosh | Kosh |
 Tony AlcantarChef | Chef |
| LLaurie BekkerOfficer #4 | Officer #4 |
| MMargot BernerSarah | Sarah |
| LLindsay BourneVet | Vet |
| CChad ColeOfficer #5 | Officer #5 |
 Dolores DrakeMrs. Bartlett | Mrs. Bartlett |
| IIrene KarasMarta | Marta |
 Ellen KennedyMother Agnes | Mother Agnes |
 Kathryn KirkpatrickSister Helen | Sister Helen |
| KKarina MacKenzieBride | Bride |
| JJamie PaytonOfficer #3 | Officer #3 |
| TTalia RangerJaney | Janey |
| CCornell TurnerOfficer #6 | Officer #6 |
| SSusie WallReporter | Reporter |
| SScott WatsonDetective Benneson | Detective Benneson |
 Barry BostwickThomas Trundle | Thomas Trundle |
 Jessica AmleeMary | Mary |
| SScott WatsonDetective Brantson | Detective Brantson |
 Ian ThompsonFirefighter | Firefighter |