Charming Sinners was a stilted adaptation of Somerset Maugham's play The Constant Wife. Robert Miles (Clive Brook) starts the ball rolling when he falls in love with Anne-Marie Whitley (Mary Nolan), the best friend of his own wife Kathryn (Ruth Chatterton). In retaliation, Kathryn begins a flirtation with her former boyfriend Karl Kraley (William Powell). After reels and reels of verbal fencing, the status quo is re-established, and Robert and Kathryn are reunited.
| Actor | Role |
|---|---|
 Ruth ChattertonKathryn Miles | Kathryn Miles |
 Clive BrookRobert Miles | Robert Miles |
 Mary NolanAnne-Marie Whitley | Anne-Marie Whitley |
 William PowellKarl Kraley | Karl Kraley |
 Laura Hope CrewsMrs. Carr | Mrs. Carr |
 Florence EldridgeHelen Carr | Helen Carr |
 Montagu LoveGeorge Whitley | George Whitley |
| JJuliette CrosbyMargaret | Margaret |
| LLorraine MacLeanAlice | Alice |
| CClaud AllisterGregson | Gregson |