Wilbur the pig knows how important friendship is - he learned that from a spider named Charlotte. So when Wilbur meets Cardigan, a lonely lamb, Wilbur immediately makes him his friend.
| Actor | Role |
|---|---|
 Julia DuffyCharlotte (voice) | Charlotte (voice) |
| DDavid BerónWilbur | Wilbur |
 Charlie AdlerTempleton / Lurvy (voice) | Templeton / Lurvy (voice) |
 Amanda BynesNellie | Nellie |
 Maria BamfordAranea (voice) | Aranea (voice) |
 Debi DerryberryFern | Fern |
 Laraine NewmanGwen (voice) | Gwen (voice) |
 Anndi McAfeeJoy (voice) | Joy (voice) |
 Harrison ChadCardigan | Cardigan |
 Rob PaulsenFarley | Farley |
 Dawnn LewisBessie | Bessie |
 Brenda VaccaroMrs. Hirsch | Mrs. Hirsch |
 Jerry HouserMr. Zuckerman | Mr. Zuckerman |
| VValery PappasHigh Strung Chicken | High Strung Chicken |
 Nika FuttermanBaby Rats | Baby Rats |