 Tom HanksCharlie Wilson | Charlie Wilson |
 Julia RobertsJoanne Herring | Joanne Herring |
 Philip Seymour HoffmanGust Avrakotos | Gust Avrakotos |
 Amy AdamsBonnie Bach | Bonnie Bach |
 Emily BluntJane Liddle | Jane Liddle |
 Om PuriPresident Zia | President Zia |
 Shiri ApplebyJailbait - Charlie's Angels | Jailbait - Charlie's Angels |
 Rachel NicholsSuzanne - Charlie's Angels | Suzanne - Charlie's Angels |
 Wynn EverettReceptionist - Charlie's Angel | Receptionist - Charlie's Angel |
 Jud TylorCrystal Lee | Crystal Lee |
 John SlatteryCravely | Cravely |
 Erick AvariAvi Perlman | Avi Perlman |
 Cyia BattenStacey | Stacey |
 Denis O'HareHarold Holt | Harold Holt |
 Ned BeattyDoc Long | Doc Long |
 Ken StottZvi | Zvi |
 Daniel Eric GoldDonnelly | Donnelly |
 Harry S. MurphyCongressional Committee | Congressional Committee |
 Enayat DelawaryDoc Long's Translator | Doc Long's Translator |
 Peter GeretyLarry Liddle | Larry Liddle |
 Navid NegahbanRefugee Camp Translator | Refugee Camp Translator |
 P.J. ByrneJim Van Wagenen | Jim Van Wagenen |
 Mozhan NavabiRefugee Camp Translator #2 | Refugee Camp Translator #2 |
| MMichael SpellmanAgent Patrick | Agent Patrick |
 Russell EdgeAgent Wells | Agent Wells |
 Christopher DenhamMike Vickers | Mike Vickers |
 Ron FasslerMario | Mario |
 Nazanin BoniadiAfghan Refugee Woman (uncredited) | Afghan Refugee Woman (uncredited) |
 Rizwan ManjiColonel Mahmood | Colonel Mahmood |
 Tracy PhillipsBelly dancer | Belly dancer |
