Nine-year-old Danny teams up with his beloved family dog Charlie, who gets abducted by aliens and returns with superpowers, to thwart a plan by the neighbor's sinister cat Puddy to destroy humanity.
| Actor | Role |
|---|---|
 Owen WilsonCharlie (voice) | Charlie (voice) |
 Ruairi MacDonaldPuddy (voice) | Puddy (voice) |
 Dawson LittmanDanny (voice) | Danny (voice) |
 Tabitha St. GermainPresident Rose (voice) | President Rose (voice) |
 Vincent TongPresident's Aid (voice) | President's Aid (voice) |
| EElishia PerosaMom (voice) | Mom (voice) |
 Sebastian Billingsley-RodriguezAlien Prince (voice) | Alien Prince (voice) |
 Rhona ReesAlien Queen (voice) | Alien Queen (voice) |
| SShawn YoungchiefAlien Head Commander (voice) | Alien Head Commander (voice) |
 Anthony BologneseJacob (voice) | Jacob (voice) |
 Caitlynne MedrekKitten (voice) | Kitten (voice) |
 Emily DelahuntyEmma (voice) | Emma (voice) |
 Mela PietropaoloMadison (voice) | Madison (voice) |
 Lindsay GibsonJudge Gruff (voice) | Judge Gruff (voice) |
| JJenn RoganSam (voice) | Sam (voice) |
| ZZac Bennett-McPheeOtis (voice) | Otis (voice) |
 Devon BusswoodSlinky (voice) | Slinky (voice) |
 David DixonFood Vendor / Stinky (voice) | Food Vendor / Stinky (voice) |
| NNicole BoumaInfluencer (voice) | Influencer (voice) |