 Sidney TolerCharlie Chan | Charlie Chan |
 Victor Sen YungJimmy Chan | Jimmy Chan |
 Leo G. CarrollProfessor Gordon | Professor Gordon |
 Lionel AtwillDr. Suderman | Dr. Suderman |
 Robert LoweryDick Kenyon | Dick Kenyon |
 Marjorie WeaverPaula Drake | Paula Drake |
 Cora WitherspoonSusie Watson | Susie Watson |
 Don BeddoeFrederick Ross | Frederick Ross |
 Leonard MudieGerald Pendleton | Gerald Pendleton |
 Charles MiddletonJeremiah Walters | Jeremiah Walters |
 Claire Du BreySarah Walters | Sarah Walters |
 James BurkeWilkie, house detective | Wilkie, house detective |
 Richard KeeneButtons, ship's steward | Buttons, ship's steward |
 Harry StrangSeaman Guarding Pendleton | Seaman Guarding Pendleton |
 Harlan BriggsSan Francisco Coroner | San Francisco Coroner |
 Layne Tom Jr.Willie Chan | Willie Chan |
 C. Montague ShawInspector Duff | Inspector Duff |
 Cliff ClarkLieutenant Wilson | Lieutenant Wilson |
 Kay LinakerLinda Pendleton | Linda Pendleton |
 Paul McVeyMrs. Pendleton's Doctor | Mrs. Pendleton's Doctor |
 Wade BotelerHonolulu Police Chief | Honolulu Police Chief |
 Emmett VoganHotel Manager | Hotel Manager |
 John DilsonPolice Doctor at Hotel | Police Doctor at Hotel |
 J. Anthony HughesDetective Wilson, Chan's agent | Detective Wilson, Chan's agent |
| SSherry HallRadio Operator (uncredited) | Radio Operator (uncredited) |
 Walter MillerShip's Officer (uncredited) | Ship's Officer (uncredited) |
 Al KikumeCop Extra in Chan's Office | Cop Extra in Chan's Office |
