 James MarsdenDiggs (voice) | Diggs (voice) |
 Nick NolteButch (voice) | Butch (voice) |
 Christina ApplegateCatherine (voice) | Catherine (voice) |
 Bette MidlerKitty Galore (voice) | Kitty Galore (voice) |
 Pascale HuttonJackie | Jackie |
 Katt WilliamsSeamus (voice) | Seamus (voice) |
 Neil Patrick HarrisLou (voice) | Lou (voice) |
 Sean HayesMr. Tinkles (voice) | Mr. Tinkles (voice) |
 Wallace ShawnCalico (voice) | Calico (voice) |
 Roger MooreTab Lazenby (voice) | Tab Lazenby (voice) |
 Joe PantolianoPeek (voice) | Peek (voice) |
 Michael Clarke DuncanSam (voice) | Sam (voice) |
 Chris O'DonnellShane | Shane |
 Jack McBrayerChuck | Chuck |
 Fred ArmisenFreidrich | Freidrich |
 Kiernan ShipkaLittle Girl | Little Girl |
 Paul RodríguezCrazy Carlito (voice) | Crazy Carlito (voice) |
 J.K. SimmonsGruff K-9 (voice) | Gruff K-9 (voice) |
 E. G. DailyScrumptious / Patches / Catherine's Niece (voice) | Scrumptious / Patches / Catherine's Niece (voice) |
 Phil LaMarrPaws / Cat Spy Analyst (voice) | Paws / Cat Spy Analyst (voice) |
 Michael BeattieAngus MacDougall (voice) | Angus MacDougall (voice) |
 Jeff BennettDuncan MacDougall (voice) | Duncan MacDougall (voice) |
| MMalcolm StewartCaptain Flemming | Captain Flemming |
 Dawn ChubaiReporter | Reporter |
 Keith DallasCoit Tower Guard | Coit Tower Guard |
| LLen MorgantiRex (voice) | Rex (voice) |
 Betty PhillipsCat Lady | Cat Lady |
 Christopher Lee ParsonHep Cat / Cat Spy Analyst (voice) | Hep Cat / Cat Spy Analyst (voice) |
 Bumper RobinsonCool Cat / Dog Killa / Cat Spy Analyst / Slim (voice) | Cool Cat / Dog Killa / Cat Spy Analyst / Slim (voice) |
 Rick D. WassermanRocky (voice) | Rocky (voice) |
