CatDog are on a quest to find their parents.
| Actor | Role |
|---|---|
 Carlos AlazraquiWinslow (voice) | Winslow (voice) |
 Jim CummingsCat (voice) | Cat (voice) |
 Tom KennyDog / Cliff (voice) | Dog / Cliff (voice) |
 Jane KrakowskiCatDog's Mother / Pussycat Catfield (voice) | CatDog's Mother / Pussycat Catfield (voice) |
 Dwight SchultzEddie (voice) | Eddie (voice) |
 Billy Bob ThorntonHound Dog McDog / CatDog's Step-father (voice) | Hound Dog McDog / CatDog's Step-father (voice) |
 Frank WelkerBessie the Sea Monster (voice) | Bessie the Sea Monster (voice) |
 Maria BamfordShriek Dubois (voice) | Shriek Dubois (voice) |
 Billy WestRancid Rabbit (voice) | Rancid Rabbit (voice) |
 Nika FuttermanLola (voice) | Lola (voice) |