Troubled author John Kennedy Toole's struggle to bring A Confederacy of Dunces to print.
| Actor | Role |
|---|---|
 Cary ElwesKingsley Amis | Kingsley Amis |
 Diane KrugerPatricia Rickels | Patricia Rickels |
 Marie AvgeropoulosJean Ann Jollett | Jean Ann Jollett |
 Brad DourifArthur Ducoing | Arthur Ducoing |
 Nick OffermanBobby Byrne | Bobby Byrne |
 Thomas MannJohn Kennedy Toole | John Kennedy Toole |
 Susan SarandonThelma Toole | Thelma Toole |
 Desmond HarringtonJack Kerouac | Jack Kerouac |
 Annalise BassoMartha | Martha |
 Aidan QuinnBarnet Rosset | Barnet Rosset |
 Skyler SamuelsRuth | Ruth |
 Stephen TobolowskyThe Abbot | The Abbot |
 François ArnaudDave Kubach | Dave Kubach |
 Brendan CoyleMilton Rickels | Milton Rickels |
 Denis O'HareJohn Dewey Toole | John Dewey Toole |
 Roger BartLes Phillabaum | Les Phillabaum |
 David PaymerStanley Kauffmann | Stanley Kauffmann |
 Nick GehlfussJoel Fletcher | Joel Fletcher |
 Arliss HowardShelby Foote | Shelby Foote |
 Olivia CrocicchiaMyrna | Myrna |
 Billy SlaughterNot listed | Not listed |