 Edward G. RobinsonLittle John T. 'Johnny' Sarto | Little John T. 'Johnny' Sarto |
 Ann SothernFlorence 'Flo' Addams | Florence 'Flo' Addams |
 Humphrey BogartJack Buck | Jack Buck |
 Donald CrispBrother Superior | Brother Superior |
 Ralph BellamyClarence P. Fletcher | Clarence P. Fletcher |
 Allen JenkinsWillie 'The Knife' Corson | Willie 'The Knife' Corson |
 Charles D. BrownBrother Wren | Brother Wren |
 Cecil KellawayBrother Goodwin | Brother Goodwin |
 Morgan ConwayPhiladelphia Powell | Philadelphia Powell |
 Richard LaneMugsy O'Day | Mugsy O'Day |
 Paul GuilfoyleRed Martin | Red Martin |
 John RidgelyTexas Pearson | Texas Pearson |
 Joseph CrehanBrother MacEwen | Brother MacEwen |
 Wilfred LucasBrother MacDonald | Brother MacDonald |
 Tom TylerCurley Matthews | Curley Matthews |
 Dick WesselBuffalo Burns | Buffalo Burns |
 Granville BatesPattonsville Superintendent | Pattonsville Superintendent |
| PPaul PhillipsFrench Frank | French Frank |
 Don RowanAl Muller | Al Muller |
| NNanette VallonFifi | Fifi |
 Tim RyanTurkey Malone | Turkey Malone |
 Joe CaitsHandsome Harry | Handsome Harry |
 Pat GleasonDopey Perkins | Dopey Perkins |
| TTommy BakerJoseph | Joseph |
| JJimmy AyeGangster (uncredited) | Gangster (uncredited) |
 Sidney BraceySteward Bringing Briefcase (uncredited) | Steward Bringing Briefcase (uncredited) |
 Harlan BriggsThomas A. Bailey - Acme Paving (uncredited) | Thomas A. Bailey - Acme Paving (uncredited) |
 Louise CarterScrub Woman at End (uncredited) | Scrub Woman at End (uncredited) |
 Charles ColemanEnglish Diamond Salesma (uncredited) | English Diamond Salesma (uncredited) |
 G. Pat CollinsTim O'Hara (uncredited) | Tim O'Hara (uncredited) |
