Kenai finds his childhood human friend Nita and the two embark on a journey to burn the amulet he gave to her before he was a bear, much to Koda's dismay.
| Actor | Role |
|---|---|
 Patrick DempseyKenai (voice) | Kenai (voice) |
 Mandy MooreNita (voice) | Nita (voice) |
 Jeremy SuarezKoda (voice) | Koda (voice) |
 Rick MoranisRutt (voice) | Rutt (voice) |
 Dave ThomasTuke (voice) | Tuke (voice) |
 Andrea MartinAnda (voice) | Anda (voice) |
 Catherine O'HaraKata (voice) | Kata (voice) |
 Wanda SykesInnoko (voice) | Innoko (voice) |
 Wendie MalickAunt Siqiniq (voice) | Aunt Siqiniq (voice) |
 Kathy NajimyAunt Taqqiq (voice) | Aunt Taqqiq (voice) |
 Michael Clarke DuncanTug (voice) | Tug (voice) |
 Jim CummingsBering / Chilkoot (voice) | Bering / Chilkoot (voice) |
 Jeff BennettAdditional Voices (voice) | Additional Voices (voice) |
 Michaela Jill MurphyAdditional Voices (voice) | Additional Voices (voice) |
| JJack WeberAdditional Voices (voice) | Additional Voices (voice) |
 Tress MacNeilleAdditional Voices (voice) | Additional Voices (voice) |