The story of professional football players Gale Sayes and Brian Piccolo, and how their friendship on and off the field was affected when Piccolo contracted a fatal disease
| Actor | Role |
|---|---|
 Sean MaherBrian Piccolo | Brian Piccolo |
 Mekhi PhiferGale Sayers | Gale Sayers |
| PPaula CaleJoy Piccolo | Joy Piccolo |
 Elise NealLinda Sayers | Linda Sayers |
 Ben GazzaraCoach Halas | Coach Halas |
 Aidan DevineAbe Gibron | Abe Gibron |
 Bruce GoochEd McCaskey | Ed McCaskey |
 Craig EldridgeDoctor Beattie | Doctor Beattie |
 Dean McDermottRalph Kurek | Ralph Kurek |
| EErika CohenNurse | Nurse |
| JJeff IroniDick Butkus | Dick Butkus |
 Michael BoisvertJack Concannon | Jack Concannon |
 Michael MillarDoctor Fox | Doctor Fox |
 Shane DalyBill Filbert | Bill Filbert |
 Shawn LawrenceDoctor O'Conner | Doctor O'Conner |