The Black Mask must stop a group intent on setting off a DNA bomb that could cause mutations to the human race.
| Actor | Role |
|---|---|
 Andy On Chi-KitBlack Mask / Kan Fung | Black Mask / Kan Fung |
 Tobin BellMoloch | Moloch |
 Jon PolitoKing | King |
| TTeresa Maria HerreraDr. Marco Leung | Dr. Marco Leung |
 Scott AdkinsDr. Lang | Dr. Lang |
 Rob SzatkowskiClaw | Claw |
 Tyler ManeThorn | Thorn |
 Oris ErhueroWolf | Wolf |
 Sean MarquetteRaymond | Raymond |
 Robert Allen MukesSnake | Snake |
 Michael Bailey SmithRoss | Ross |
 Andrew BryniarskiIguana | Iguana |
 Traci LordsChameleon | Chameleon |
 Blackie Ko Sau-LeungInspector | Inspector |
 Silvio SimacGeneral Troy | General Troy |
 Terence Yin Chi-WaiDr. David | Dr. David |
| MMarcus FoxThai Policeman | Thai Policeman |