Ikay, a girl stricken with the skin disorder vitiligo, is often described as a living meme within her university. Upon discovering the powers of a magical black lipstick, "Icky Ikay" leads a double life as a social media influencer named Jessie. Set in a world of vlogs, dating apps and live videos, Black Lipstick reimagines the concept of beauty and acceptance in the age of social media.
| Actor | Role |
|---|---|
 Kyline AlcantaraIkay | Ikay |
 Snooky SernaNot listed | Not listed |
| MMigo AdecerNot listed | Not listed |
| MManolo PedrosaNot listed | Not listed |
 Kate ValdezNot listed | Not listed |
| TThia ThomallaNot listed | Not listed |
 Angellie Nicholle SanoyNot listed | Not listed |
| CChesca SalcedoNot listed | Not listed |
| NNella Marie DizonNot listed | Not listed |
 Eunice LagusadNot listed | Not listed |
 Angel GuardianNot listed | Not listed |
| JJames TengNot listed | Not listed |
| PPatricia RoxasNot listed | Not listed |
| NNichole VillanuevaNot listed | Not listed |
 Phi PalmosNot listed | Not listed |