 Richard Steven HorvitzBilly / Billybot / Harold / Pale Ghoulish Juror / Chippy the Squirrel (voice) (as Richard Horvitz) | Billy / Billybot / Harold / Pale Ghoulish Juror / Chippy the Squirrel (voice) (as Richard Horvitz) |
 Grey DeLisleMandy / Mandroid / Older Mandy / Milkshakes / Some Kid (voice) | Mandy / Mandroid / Older Mandy / Milkshakes / Some Kid (voice) |
 Greg EaglesGrim / Sperg / Pirate #6 | Grim / Sperg / Pirate #6 |
 Vanessa MarshallIrwin / Pirate #5 / Unicorn (voice) | Irwin / Pirate #5 / Unicorn (voice) |
 Maxwell AtomsI'll Cut You Guy / Pirate #2 / Horrorbot / Burnt Skeleton Guard (voice) | I'll Cut You Guy / Pirate #2 / Horrorbot / Burnt Skeleton Guard (voice) |
| GGeorge BallPeequay (voice) | Peequay (voice) |
 Jane CarrBride of Frankenstein (voice) | Bride of Frankenstein (voice) |
 Greg EllisCreeper / Horror's Hand / Pirate #3 / Paperboy (voice) | Creeper / Horror's Hand / Pirate #3 / Paperboy (voice) |
 Bart FlynnGiant Cyclops / Ugly Pirate (voice) | Giant Cyclops / Ugly Pirate (voice) |
 C.H. GreenblattFred Fredburger / Pirate #4 (voice) | Fred Fredburger / Pirate #4 (voice) |
 Jennifer HaleBilly's Mom (voice) | Billy's Mom (voice) |
 Dorian HarewoodOlder Irwin (voice) | Older Irwin (voice) |
 Phil LaMarrSpace Villain / Glacier of Evil / Dracula / Judge Roy Spleen / Underworld Cop (voice) | Space Villain / Glacier of Evil / Dracula / Judge Roy Spleen / Underworld Cop (voice) |
 Rachael MacFarlane2 Headed Parrot (voice) | 2 Headed Parrot (voice) |
 George SegalHorror (voice) | Horror (voice) |
 Armin ShimermanGeneral Skarr / Pirate #7 (voice) | General Skarr / Pirate #7 (voice) |
| JJames SilvermanExecutioner / Pirate #1 (voice) | Executioner / Pirate #1 (voice) |
 Lauren TomNumbuh Three (voice) | Numbuh Three (voice) |
 Billy WestPirate #8 / Miniature Cyclops / Spider Clown Mailman / Beast Master (voice) | Pirate #8 / Miniature Cyclops / Spider Clown Mailman / Beast Master (voice) |
 Fred WillardThe Boogey Man (voice) | The Boogey Man (voice) |
