In 1997, rap superstars Tupac Shakur and Christopher Wallace (aka Biggie Smalls, The Notorious B.I.G.) were gunned down in separate incidents, the apparent victims of hip hop's infamous east-west rivalry. Nick Broomfield's film introduces Russell Poole, an ex-cop with damning evidence that suggests the LAPD deliberately fumbled the case to conceal connections between the police, LA gangs and Death Row Records, the label run by feared rap mogul Marion "Suge" Knight.
| Actor | Role |
|---|---|
 Tupac Shakurhimself | himself |
 Nick Broomfieldhimself | himself |
 The Notorious B.I.G.Himself (archive footage) | Himself (archive footage) |
| RRussell PooleHimself | Himself |
 Voletta WallaceSelf - Biggie's Mother | Self - Biggie's Mother |
| BBilly GarlandSelf - Tupac's Biological Father | Self - Tupac's Biological Father |
| CChico Del VecSelf - Rapper | Self - Rapper |
| DDon SeaboldSelf - Mark's Lawyer | Self - Mark's Lawyer |
| DDonald HickenSelf - Tupac's Teacher | Self - Tupac's Teacher |
| FFrank AlexanderSelf - Tupac's Bodyguard | Self - Tupac's Bodyguard |
| KKevin HackieSelf - Tupac's Bodyguard | Self - Tupac's Bodyguard |
| MMarshall BigtowerSelf - Sonia's Lawyer | Self - Sonia's Lawyer |
| MMopreme ShakurSelf - Tupac's Stepbrother | Self - Tupac's Stepbrother |
| RReggie Wright Sr.Self - Chief Gangs Officer | Self - Chief Gangs Officer |
| SSonia FloresSelf - Officer Perez's Girlfriend | Self - Officer Perez's Girlfriend |
| GGene DealSelf - Biggie's Bodyguard | Self - Biggie's Bodyguard |