A student receives a serial killer's brain in a transplant after being thrown into a pool with no water in it.
| Actor | Role |
|---|---|
 Matthew LawrenceFrank Stein | Frank Stein |
 Ryan ReynoldsKarl O'Reilly | Karl O'Reilly |
 Justin WalkerLance Kipple | Lance Kipple |
 Christine LakinMacy | Macy |
 Shelley DuvallMrs. Stein | Mrs. Stein |
 Judge ReinholdMr. Stein | Mr. Stein |
 Richard MollMr. O'Reilly | Mr. O'Reilly |
| CChristian PayneTuttle | Tuttle |
 Charles FleischerMr. Stockton | Mr. Stockton |
 Kenn MichaelJordy | Jordy |
 Bianca LawsonDarien Stompanato | Darien Stompanato |
 Nicole NiethAndrea Shrelonzky | Andrea Shrelonzky |
| BBradley Jay LesleyArnie | Arnie |
 Eric SiegelOfficer Scott | Officer Scott |
 Richard Speight Jr.Comic Book Salesman | Comic Book Salesman |