After a family tragedy, three generations of the Deetz family return home to Winter River. Still haunted by Betelgeuse, Lydia's life is turned upside down when her teenage daughter, Astrid, accidentally opens the portal to the Afterlife.
| Actor | Role |
|---|---|
 Michael KeatonBeetlejuice | Beetlejuice |
 Winona RyderLydia | Lydia |
 Catherine O'HaraDelia | Delia |
 Jenna OrtegaAstrid | Astrid |
 Justin TherouxRory | Rory |
 Willem DafoeJackson | Jackson |
 Monica BellucciDelores | Delores |
 Arthur ContiJeremy | Jeremy |
 Nick KellingtonBob - Shrinker | Bob - Shrinker |
 Santiago CabreraRichard | Richard |
 Burn GormanFather Damien | Father Damien |
 Danny DeVitoJanitor | Janitor |
 Sami SlimaneLe Tigre | Le Tigre |
 Amy NuttallJane Butterfield | Jane Butterfield |
 Mark HeenehanClive | Clive |
 Charlie HopkinsonClive (voice) | Clive (voice) |
 Liv SpencerOlga | Olga |
 Skylar ParkLittler Jane | Littler Jane |
 Jane LeaneyJeremy's Mom | Jeremy's Mom |
 David AyresJeremy's Dad | Jeremy's Dad |
 Sophie HollandHot Dog Lady on a Stick | Hot Dog Lady on a Stick |
 Walles HamondeGlen - Director | Glen - Director |
 Max PembertonSurfer Dude | Surfer Dude |
 Rebecca O'MaraJody Welch | Jody Welch |
 Adam SpeersEmmet Welch | Emmet Welch |
 Daryl KwanEddy | Eddy |
 Caroline LawrieDead Cat Lady | Dead Cat Lady |
 Philip PhilmarHooded Pagan | Hooded Pagan |
 Stephen K. AmosConductor | Conductor |
 Sean VerreJosh | Josh |