After everyone's favorite St. Bernard gets fired from a movie, Beethoven begins the long journey home with his trainer, Eddie. On their way, they become stranded in a small coastal town where the beloved canine befriends a young boy who is searching for buried treasure.
| Actor | Role |
|---|---|
 Jonathan SilvermanEddie Thornton | Eddie Thornton |
 Kristy SwansonAnne Parker | Anne Parker |
 Jayne EastwoodGrace O'Malley | Grace O'Malley |
 David DeLuisePhil | Phil |
| BBretton ManleySam Parker | Sam Parker |
 Jeffrey CombsFritz Bruchschnauser / Howard Belch | Fritz Bruchschnauser / Howard Belch |
 Alec MapaSimon | Simon |
 Brian GeorgeTrentino | Trentino |
 Udo KierThe Real Fritz Bruchschnauser | The Real Fritz Bruchschnauser |
 Colin MochrieDr. Kelp | Dr. Kelp |
 Morgan FairchildCharlene | Charlene |
 Patrick Kwok-ChoonJustin | Justin |
| IIan TenchFilm Crew Member | Film Crew Member |
| NNikki BarnettAssistant Director | Assistant Director |
 Brian DowneyNorman the Magician | Norman the Magician |
| JJ. Thomas ScottCaptain Patrick O'Malley | Captain Patrick O'Malley |
| JJacob SampsonBurly Crew Man | Burly Crew Man |
| OOnika DrabbleSandra | Sandra |
| KKatherine ShoreCallie | Callie |
| AAaliyah ArabLittle Girl with Bike | Little Girl with Bike |
| MMarguerite McNeilLady at Bus Stop | Lady at Bus Stop |
 Dee Bradley BakerAnimal Sounds (voice) | Animal Sounds (voice) |
| RRichard DumontDuncan | Duncan |