 Paul GiamattiBarney Panofsky | Barney Panofsky |
 Dustin HoffmanIzzy Panofsky | Izzy Panofsky |
 Rosamund PikeMiriam Grant-Panofsky | Miriam Grant-Panofsky |
 Minnie DriverThe 2nd Mrs. P | The 2nd Mrs. P |
 Scott SpeedmanBoogie | Boogie |
 Rachelle LefevreClara 'Chambers' Charnofsky | Clara 'Chambers' Charnofsky |
 Bruce GreenwoodBlair | Blair |
 Mark AddyDetective O'Hearne | Detective O'Hearne |
 Macha GrenonSolange | Solange |
 Jake HoffmanMichael Panofsky | Michael Panofsky |
 Anna HopkinsKate Panofsky | Kate Panofsky |
 Saul RubinekCharnofsky | Charnofsky |
 Harvey Atkin2nd Mrs. P's Father | 2nd Mrs. P's Father |
 Linda Sorensen2nd Mrs. P's Mother | 2nd Mrs. P's Mother |
 Brittany DrisdelleGirl at Cafe | Girl at Cafe |
 Thomas TrabacchiLeo | Leo |
 Clé BennettCedric | Cedric |
 Paul GrossConstable O'Malley of the North | Constable O'Malley of the North |
 Maury ChaykinWedding Guest | Wedding Guest |
 Larry DayBartender at Wedding | Bartender at Wedding |
 Mark CamachoT / U Productions Executive #1 | T / U Productions Executive #1 |
 Harry StandjofskiDr. Morty | Dr. Morty |
 Atom EgoyanO'Malley Director #1 | O'Malley Director #1 |
 David CronenbergO'Malley Director #2 | O'Malley Director #2 |
 Ted KotcheffTrain Conductor | Train Conductor |
| DDavid PrydeT / U Productions Executive #1 | T / U Productions Executive #1 |
 Paula Jean HixsonBartender at Grumpy's | Bartender at Grumpy's |
| MMarica PellegrinelliThe Countess | The Countess |
 Domenico MinutoliJudge at Rome Wedding | Judge at Rome Wedding |
 Massimo WertmüllerRome Doctor | Rome Doctor |
