An outcast half-wolf risks his life to prevent a deadly epidemic from ravaging Nome, Alaska.
| Actor | Role |
|---|---|
 Kevin BaconBalto (voice) | Balto (voice) |
 Bob HoskinsBoris the Goose (voice) | Boris the Goose (voice) |
 Bridget FondaJenna (voice) | Jenna (voice) |
 Jim CummingsSteele the Sled Dog (voice) | Steele the Sled Dog (voice) |
 Phil CollinsMuk and Luk (voice) | Muk and Luk (voice) |
 Juliette BrewerYoung Rosy (voice) | Young Rosy (voice) |
 Jack AngelNikki (voice) | Nikki (voice) |
 Danny MannKaltag (voice) | Kaltag (voice) |
 Robbie RistStar (voice) | Star (voice) |
 Sandra DickinsonDixie / Sylvie (voice) | Dixie / Sylvie (voice) |
 Frank WelkerGrizzly Bear (voice) | Grizzly Bear (voice) |
 Miriam MargolyesGrandma Rosy | Grandma Rosy |
| LLola Bates-CampbellRosy's granddaughter | Rosy's granddaughter |
 Donald SindenDoc (voice) | Doc (voice) |
 Garrick HagonTelegraph Operator (voice) | Telegraph Operator (voice) |
 William RobertsRosy's Father (voice) | Rosy's Father (voice) |
| BBig AlTown Dog (voice) | Town Dog (voice) |
| BBill BaileyButcher (voice) | Butcher (voice) |