In this sequel to "And Baby Makes Six," a middle-aged couple deals with familial upheaval after giving birth to an unplanned fourth baby --- 17 years after their last child.
| Actor | Role |
|---|---|
 Colleen DewhurstAnna Kramer | Anna Kramer |
 Warren OatesMichael Kramer | Michael Kramer |
 Devon EricsonElizabeth Kramer Winston | Elizabeth Kramer Winston |
 Fredric LehneFranklin Kramer | Franklin Kramer |
| CChris MarcantelJason Kramer | Jason Kramer |
 Mildred DunnockSerena Fox | Serena Fox |
 Paul McCraneBobby Moore | Bobby Moore |
 Dena DietrichDora | Dora |
 James NobleDr. Elliott Olsen | Dr. Elliott Olsen |
 Lee WallaceSam Blumenkrantz | Sam Blumenkrantz |
 David HuffmanJeff Winston | Jeff Winston |
 Floyd LevineLouis Zambello | Louis Zambello |
| TToni GellmanLoretta Zambello | Loretta Zambello |
 Maria MelendezMarta Montez | Marta Montez |
 Mel StewartMr. Adams | Mr. Adams |
| JJohn MediciOfficer Caputo | Officer Caputo |
 Janice KentYoung Pretty Female | Young Pretty Female |
| AArchie LangDelivery Room Doctor | Delivery Room Doctor |
| CCarol Ann WilliamsYoung Nurse | Young Nurse |
| GGeorgie PaulOlder Nurse | Older Nurse |
| GGeorge CarollUmberto | Umberto |
| RRobert ArmstrongBaby | Baby |