Debbie Wilkins escapes from Hollywood and heads east to Oklahoma City to link up with her older sister Fran after she is released from an insane asylum for her murder spree on the set of "The Bayou Butcher" in Axe to Grind. Soon after their reunion, the two sisters embark on a wild and bloody cross country road trip to evade law enforcement after Debbie does away with her parole officer. Meanwhile, Rikki, the younger sister of Nikki who Debbie dispatched of in the first movie, elicits information from Debbie's old flame Peter Burgess in order to track down Debbie and exact her revenge.
| Actor | Role |
|---|---|
 Stormy DanielsFran Wilkins | Fran Wilkins |
 Debbie RochonDebbie Wilkins | Debbie Wilkins |
| AAdrian QuihuisNorman Poindexter | Norman Poindexter |
 Matthew James GulbransonPeter Burgess | Peter Burgess |
 Shawn C. PhillipsWitness | Witness |
 Julie Anne PrescottDetective | Detective |
 Erin Marie GarrettRikki Tolman | Rikki Tolman |
| BBrett WagnerRadio DJ | Radio DJ |
| MMark D ValentiCSI Agent | CSI Agent |
| RRachel E HoffmanHoney Voodoo | Honey Voodoo |
 BJ MezekRandy | Randy |
| RRuss AndradeDetective Redford | Detective Redford |
 Johnny HuangJake | Jake |
 Denny NolanMcCain | McCain |
 Brandon KrumWoody | Woody |
| KKelsey ZukowskiTeen Debbie Wilkins | Teen Debbie Wilkins |
| CCara NicoleDarla | Darla |
| SScarlett CherryDancer | Dancer |
 Mark SchaeferFred | Fred |
| VVictor TrippodoAgent Diamonte | Agent Diamonte |