In the wake of the devastating war against the RDA and the loss of their eldest son, Jake Sully and Neytiri face a new threat on Pandora: the Ash People, a violent and power-hungry Na'vi tribe led by the ruthless Varang. Jake's family must fight for their survival and the future of Pandora in a conflict that pushes them to their emotional and physical limits.
| Actor | Role |
|---|---|
 Sam WorthingtonJake | Jake |
 Zoe SaldañaNeytiri | Neytiri |
 Sigourney WeaverKiri | Kiri |
 Stephen LangQuaritch | Quaritch |
 Oona ChaplinVarang | Varang |
 Jack ChampionSpider | Spider |
 Kate WinsletRonal | Ronal |
 Cliff CurtisTonowari | Tonowari |
 Joel David MooreNorm | Norm |
 CCH PounderMo'at | Mo'at |
 Edie FalcoGeneral Ardmore | General Ardmore |
 Brendan CowellScoresby | Scoresby |
 Jemaine ClementDr. Garvin | Dr. Garvin |
 Giovanni RibisiSelfridge | Selfridge |
 David ThewlisPeylak | Peylak |
 Britain DaltonLo'ak | Lo'ak |
 Trinity Jo-Li BlissTuk | Tuk |
 Jamie FlattersNeteyam | Neteyam |
 Bailey BassTsireya | Tsireya |
 Filip GeljoAonung | Aonung |
 Duane Evans Jr.Rotxo | Rotxo |
 Matt GeraldRecom Wainfleet | Recom Wainfleet |
 Dileep RaoMax Patel | Max Patel |
| DDaniel LoughSpider Double | Spider Double |
 Kevin DormanArdmore Adjutant / Troupe | Ardmore Adjutant / Troupe |
 Keston JohnTarsem | Tarsem |
 Alicia Vela-BaileyIkeyni / Troupe | Ikeyni / Troupe |
 Johnny AlexanderRiku / Troupe | Riku / Troupe |
 Jamie LandauOps Centre Weapons Officer / Troupe | Ops Centre Weapons Officer / Troupe |
 Graham VincentOps Centre Weapons Tech | Ops Centre Weapons Tech |