 Freddie HighmoreAstro / Toby (voice) | Astro / Toby (voice) |
 Kristen BellCora (voice) | Cora (voice) |
 Nathan LaneHamegg (voice) | Hamegg (voice) |
 Eugene LevyOrrin (voice) | Orrin (voice) |
 Matt LucasSparx (voice) | Sparx (voice) |
 Bill NighyDr. Elefun / Robotsky (voice) | Dr. Elefun / Robotsky (voice) |
 Donald SutherlandPresident Stone (voice) | President Stone (voice) |
 Charlize Theron"Our Friends" Narrator (voice) | "Our Friends" Narrator (voice) |
 Nicolas CageDr. Tenma (voice) | Dr. Tenma (voice) |
 Madeline CarrollWidget (voice) | Widget (voice) |
 Sterling BeaumonSludge (voice) | Sludge (voice) |
 Samuel L. JacksonZog (voice) | Zog (voice) |
 David Alan GrierMr. Squirt / Math Cowboy / Boxer Robot (voice) | Mr. Squirt / Math Cowboy / Boxer Robot (voice) |
 Alan TudykMr. Squeegee / Scrapheap Head / Stinger Two (voice) | Mr. Squeegee / Scrapheap Head / Stinger Two (voice) |
 Newell AlexanderGeneral Heckler (voice) | General Heckler (voice) |
 Elle FanningGrace (voice) | Grace (voice) |
 Pilar FlynnCora's Mom (voice) | Cora's Mom (voice) |
 Dee Bradley BakerTrashcan (voice) | Trashcan (voice) |
 Moisés AriasZane (voice) | Zane (voice) |
 Ryan StilesMr. Moustachio / Burning Robot (voice) | Mr. Moustachio / Burning Robot (voice) |
 David BowersMike the Fridge (voice) | Mike the Fridge (voice) |
| SSofia BowersThe Little Stinker (voice) | The Little Stinker (voice) |
| NNicole Fletcher"Oh No!" Kid (voice) | "Oh No!" Kid (voice) |
| MMaryann GargerDr. Pigknuckle / Newscaster (voice) | Dr. Pigknuckle / Newscaster (voice) |
 Tiffany HillkurtzBride to Be (voice) | Bride to Be (voice) |
 David FeissCowboy Robot (voice) | Cowboy Robot (voice) |
 Nicholas GuestFrench Waiter Robot (voice) | French Waiter Robot (voice) |
 Max BurkholderBilly (voice) | Billy (voice) |
| VVictor BonavidaSam (voice) | Sam (voice) |
 Steve AltermanPress Secretary (voice) | Press Secretary (voice) |
