Strife and disaster befall a poor Mississippi family during a two-day trip by horse and wagon to bury their deceased matriarch.
| Actor | Role |
|---|---|
 James FrancoDarl Bundren | Darl Bundren |
 Danny McBrideVernon Tull | Vernon Tull |
 Logan Marshall-GreenJewel | Jewel |
 Ahna O'ReillyDewey Dell | Dewey Dell |
 Jim ParrackCash | Cash |
 Tim Blake NelsonAnse | Anse |
 Beth GrantAddie Bundren | Addie Bundren |
| JJennifer Kristen HowellCora Tull | Cora Tull |
 Brady PermenterVardaman Bundren | Vardaman Bundren |
| NNatalie MintonKate Tull | Kate Tull |
 Jessica Lemon WilkinsonMrs. Armstid | Mrs. Armstid |
| KKenny CookGrummet | Grummet |
 Brian LallyDr. Peabody | Dr. Peabody |
 Anna KoorisEula Tull | Eula Tull |
| VVince JolivetteYoung Whitfield | Young Whitfield |
 Scott HazeSkeet McGowan | Skeet McGowan |
 Coby BattyGillespie | Gillespie |
| JJohn StillSamson | Samson |
 Jesse HeimanJody | Jody |
| SSteve NaborsReverend Whitfield | Reverend Whitfield |