Starting from childhood attempts at illustration, the protagonist pursues his true obsession to art school. But as he learns how the art world really works, he finds that he must adapt his vision to the reality that confronts him.
| Actor | Role |
|---|---|
 Max MinghellaJerome | Jerome |
 Sophia MylesAudrey | Audrey |
 John MalkovichProfessor Sandiford | Professor Sandiford |
 Jim BroadbentJimmy | Jimmy |
 Matt KeeslarJonah | Jonah |
 Ethan SupleeVince | Vince |
 Joel David MooreBardo | Bardo |
 Nick SwardsonMatthew | Matthew |
 Anjelica HustonArt History Teacher | Art History Teacher |
 Adam ScottMarvin Bushmiller | Marvin Bushmiller |
 Jack OngProfessor Okamura | Professor Okamura |
 Scoot McNairyArmy-Jacket | Army-Jacket |
| JJeremy GuskinEno | Eno |
| MMonika RamnathFlower | Flower |
| IIsaac LaskinKiss-Ass | Kiss-Ass |
| MMike StanleyMartel Drinker | Martel Drinker |
 Brian TurkCliffy | Cliffy |
 Jeanette BroxShilo | Shilo |
 Finneus EganVegan | Vegan |
 Shelly ColeFilthy-Haired Girl | Filthy-Haired Girl |
 Jean St. JamesMom | Mom |
 Cristen CoppenPreppy Girl | Preppy Girl |
 Michael Shamus WilesDonald Baumgarten | Donald Baumgarten |
 Kate MoennigCandace | Candace |
 Ezra BuzzingtonLeslie | Leslie |
 Lauren Lee SmithBeat Girl | Beat Girl |
 Travis WalckRichard Natwick | Richard Natwick |
 Paul CollinsProfessor David Zipkin | Professor David Zipkin |
 Marshall BellLonny | Lonny |
 Chris L. McKennaMikey | Mikey |